During the COVID-19 pandemic, Phelps Health in Missouri noticed a sudden increase in central line-associated bloodstream infection (CLABSI) rates. In response, they created a multidisciplinary team to address the issue. The project team developed, trialed and reassessed multifaceted interventions for effectiveness. Two such activities included conducting daily central venous line necessity checks during morning rounds and encouraging nurses to speak with physicians daily to review and assess central venous line necessity. Additionally, facilitators presented all findings and interventions at mandatory staff meetings, and staff were provided education on their CLABSI rates, charting deficiencies and rationale for the interventions that had been implemented. As a result of this project, Phelps Health’s CLABSI rate is the lowest it has been in six years.